For what its worth ... we just drove home a BRAND NEW 2023 Hybrid EX yesterday. We picked it up in Auburn, AL, drove it down to Destin, FL area, which is about 200 miles and change (current odometer this morning is 232). We wanted to be kind to it since it was so new, so we did NOT blast down the interstate, but instead traveled the state roads, 55-65mph the whole way, and I did NOT try to "game" the mileage. Verdict: 42.8mpg. I'm VERY pleased. Super mileage, and it's not even broken in yet!
As a bonus, it was a very relaxing drive = no semi's and jerks ripping by us, plus it was closer (in distance) and only about 5min longer. Googlemaps says:
via I-85 N 3 hr 38 min 198 miles
via I-65 N 3 hr 37 min 217 miles
via US-29 N 3 hr 43 min 187 miles <<<=== as I've often found on our trips, interstates aren't always the best answer.