If it's an actual misfire, consider towing it to the dealership for service, since driving could damage the engine. The Check Engine light would probably be on.
It sounds like your "slight misfire" means hesitation? Check (or have checked) the fuel line from pump to spark plugs, for dirty injectors or fuel filters or fouled plugs, etc.
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Techron is Chevron's brand of fuel-line detergents. Detergents won't remove "water", but fuel with additives can keep injectors cleaner. Actual water isn't compressible and will damage the engine, so don't put water in fuel.